A burgeoning biotech company has moved its headquarters from California to Texas.

CG Oncology, a bladder cancer immunotherapy company, left Irvine to put down roots at a new office park in Dallas, where it has signed an eight-year lease.

Founded in 2010, the company has been rapidly growing. It reached a $7 billion valuation as it found recent success during clinical trials to eliminate bladder tumors using modified viruses. Bladder cancer is the sixth-most common cancer in the U.S, with more than 84,000 new cases in 2025, according to the National Cancer Institute.

The company’s Irvine lease was expiring at the end of August, according to a filing with the Securities and Exchange Commission. It’s unclear if the company will retain its office spaces in Emeryville and Branchburg, New Jersey, also listed in recent SEC filings. The Emeryville lease expires in August 2028.

CG Oncology did not respond to SFGATE’s request for comment as of publication. It’s unclear if it will retain any presence in Southern California.

Sarah Connors, vice president of communications and patient advocacy, told the Dallas Morning News that the move will allow the company better access to talent and new facilities, with advantages from being more centrally located in the country. “Dallas provides CG Oncology with a strategic home within one of the nation’s fastest-growing life sciences ecosystems,” Connors told the outlet. “Pegasus Park’s unique combination of research institutions, healthcare innovation, talent and connectivity supports our long-term vision while remaining consistent with our remote-first culture.”

The new 26-acre office campus in Dallas, dubbed Pegasus Park, has a big concentration of life sciences tenants.

Many formerly California-headquartered companies have relocated to Texas in recent years, from high-profile giants like Tesla to major tech companies and even the country’s largest self-storage business.

The City of Irvine expanded its trail network today with the opening of the Jeffrey Open Space Trail (JOST) Bicycle & Pedestrian Bridge, as elected officials, City staff, cyclists, and community members were the first to walk and ride onto the bridge following a ribbon-cutting ceremony.

At nearly 1,200 feet long and 15 feet wide, it is the largest pedestrian and bicycle bridge in Irvine. It spans Walnut Avenue, the Jeffrey Road Park & Ride, and the I-5 Freeway. It also connects to the Jeffrey Open Space Trail and Cypress Village Trail to the north and the JOST extension to the south.

The bridge is part of a larger regional trail network that extends from the Pacific Ocean to the Santa Ana Mountains and Cleveland National Forest, providing greater access for people walking and biking throughout Irvine and beyond.

“The Jeffrey Open Space Trail Bicycle and Pedestrian Bridge marks an important milestone in Irvine’s long-term vision for a connected and sustainable community,” said Mayor Larry Agran. “At nearly 1,200 feet, the bridge completes a vital 5-mile corridor through the heart of our City, giving residents a safer, healthier, and more enjoyable way to walk, bike, and connect with their neighborhoods and our remarkable open spaces. This project reflects Irvine’s longstanding commitment to thoughtful planning, environmental stewardship, and creating a community designed around the well-being of the people who live here.”

The Jeffrey Open Space Trail opened in 2015 with 3.5 miles of meandering trails featuring art installations that highlight the history of the area. In March 2024, work began on the bridge and a trail extension aimed at filling a gap within the trail system. The trail has been extended from Walnut to Smoke Tree and will eventually reach Barranca Parkway.

The project was supported by $14.5 million in state funding secured by U.S. Representative Dave Min (CA-47) when he served as State Senator. Caltrans provided an additional $5,056,000 for the project.

The JOST bridge includes 2,400 linear feet of steel truss railing, 40 custom-designed decorative steel plate light poles, landscaping, and 300 linear feet of decorative concrete block walls featuring Italian Villa Stone Veneer.

To put its size into perspective, the bridge stretches more than three football fields in length, the equivalent of five Boeing 747s lined up, or four times the height of the Statue of Liberty.

Irvine, Calif., July 27, 2026 — By analyzing 100,000 California Department of Forestry and Fire Protection inspection records from 2013 to 2024, researchers at the University of California, Irvine have identified the key environmental and human factors responsible for the most destructive wildfires, and they have synthesized the knowledge into a high-resolution, actionable fire risk map for the Golden State.

The team, from UC Irvine’s Department of Civil and Environmental Engineering, learned that during the 12-year study period, nearly 55,000 buildings were completely destroyed or partially damaged by fire and that 86 percent of those structures were in wildland-urban interface zones where nature meets development. The findings are outlined in a paper published in .

“We uncovered predictable features in how buildings are destroyed in California’s wildfires, which shows that the damage pattern is not random,” said lead author Somnath Bar, a UC Irvine postdoctoral scholar in civil and environmental engineering. “We have found that by identifying the precise combination of structural, environmental and weather factors involved, we can establish a comprehensive, physically interpretable framework to explain, model and project which buildings are most likely to be damaged or destroyed by fire.”

“As fire season stretches longer into the year and blazes devastate communities across California, the need for precise, actionable fire risk data has never been greater,” said Assemblywoman Cottie Petrie-Norris (D-Irvine). “Good policy starts with good data. UC Irvine’s new fire risk map gives California exactly that – a clear picture of where the danger is greatest, so we can invest in smarter building practices, targeted fuel reduction, and data-driven planning before disaster strikes rather than after.”

Connecting landscape fires to buildings

In the paper, the researchers point to environmental elements such as low dew-point temperatures, trackable by instruments, that indicate elevated atmospheric dryness. Coupled with high wind speeds, this aridity can greatly amplify the probability of property destruction in a fire. California’s natural environment, including its grasslands, mesic chaparral and mixed oak woodland areas, serves as a pathway connecting landscape fires to buildings.

The growing tendency of people to build homes in the wildland-urban interface, near the source of forest fires, has resulted in significant property damage, the researchers said. Construction in the WUI increased in the U.S. by roughly 33 percent between 1990 and 2010, adding over 12 million new structures. Between 2020 and 2022, more than 80 percent of new homes built in California were in high fire-risk areas. Many of these WUI zones exist in middle elevations, about 500 meters (1,640 feet) above sea level, where moderate slopes channel wind that can accelerate fire spread and intensity.

According to the researchers, the way buildings are designed and the materials used in their construction can also lead to heightened risk of fire damage. These elements include wooden fences, flammable siding, protruding eaves and vents that can catch burning embers as they drift through the air, resulting in ignitions.

“Fire risk is compounded when these building practices come face to face with environmental factors like atmospheric aridity, high heat, wind, and dry fuels such as trees, shrubs and grasses,” said co-author Tirtha Banerjee, UC Irvine associate professor of civil and environmental engineering.

The Palisades and Eaton fires in Southern California, which destroyed more than 16,000 structures in January 2025, demonstrated the catastrophic potential of Santa Ana wind-driven firestorms combined with topographical attributes such as proximity to forests, sloped terrain, and canyons that channel and accelerate airflow.

The UC Irvine team took these variables and more into account to develop its Wildfire Building Damage Risk Index, a first-of-its-kind, 100-meter-resolution, continuous damage probability map covering all of California. The WBDRI integrates satellite-derived environmental data, gridded fire-weather analyses and building-level structural attributes into a machine learning framework.

The researchers tested three successive model configurations, adding building flammability ratings, weather variables and environmental exposure factors, achieving as high as 88 percent prediction accuracy. Bar said the result is a spatially explicit, actionable tool for risk forecasting, defensible space planning and the development of climate-resilient infrastructure.

“Local jurisdictions and homeowners can use the WBDRI map to prioritize defensible space inspections and fuel reduction investments in zones where the probability of damage exceeds 0.55, the threshold where the return on investment for structural hardening and vegetation management is highest,” he said.

“The strong influence of building flammability on damage tells us something encouraging: Homeowners and communities are not powerless,” Bar continued. “Replacing wood fencing, upgrading siding to noncombustible materials, retrofitting eaves and installing ember-resistant vents can substantially reduce the probability that a structure is lost in a wildfire.”

He noted that the study’s findings carry actionable implications at multiple scales. At the state and regional levels, the WBDRI provides a map of damage risk that can be integrated into land-use planning, insurance risk pricing and emergency management frameworks. At the community level, fire agencies can use it to determine where pre-fire mitigation investments will have the greatest impact. At the household level, the research provides a clear, evidence-based checklist for structural hardening, starting with fences, siding, eaves and roofing.

The researchers say they would like to see agencies adopt strategies combining stricter building codes, forward-looking land-use planning and active vegetation management, particularly in WUI zones. As fire weather conditions intensify, the team argues, such integrated, data-driven approaches are essential for protecting California’s communities and built environment.

Joining Banerjee and Bar on this project was Shu Li, a UC Irvine Ph.D. candidate in civil and environmental engineering. Funding was provided by the National Science Foundation, the University of California Office of the President and the U.S. Department of Agriculture.

About the University of California, Irvine: Founded in 1965, UC Irvine is a member of the prestigious Association of American Universities and is ranked among the nation’s top 10 public universities by U.S. News & World Report. The campus has produced five Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UC Irvine has more than 36,000 students and offers 224 degree programs. It’s located in one of the world’s safest and most economically vibrant communities and is Orange County’s second-largest employer, contributing $7 billion annually to the local economy and $8 billion statewide. For more on UC Irvine, visit www.uci.edu.

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